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Orlistat Side Effects
What is Diet Pill Orlistat (Xenical,Alli)?
Although OTC Alli is half the dose of Xenical, each weight loss drug is to still be taken as one capsule three times daily.
There are several differences to be noted between Xenical and Alli, which are as follows:
How is Orlistat (Xenical, Alli) Used for Weight Loss or Obesity Treatment?
Orlistat is available in prescription form as Xenical, and over-the-counter as Alli. Xenical has been available as a weight loss drug in both the USA and Europe for over a decade now; however, the switch to the OTC version of Alli occurred only in the last few years.
Unlike sibutramine and phentermine, there is minimal absorption of orlistat into the bloodstream and the weight loss drug is therefore not associated with the systemic side effects that plight these appetite suppressants. However, because of orlistat’s mode of action, the weight loss drug is associated side effects that include flatulence, diarrhoea, oily spotting and loose oily stools.
Xenical is the prescription version of orlistat [link widoczny dla zalogowanych], while Alli is available as an OTC diet pill.While Xenical is manufactured by Roche [link widoczny dla zalogowanych], GSK owns the rights to and markets the OTC version.Alli contains 60mg of orlistat, while Xenical contains 120mg orlistat.Although OTC Alli has been shown to be clinically effective for weight loss when used in conjunction with diet in both overweight and obese patients, Xenical has superior efficacy for weight loss than Alli.Due to the lower dose of orlistat in OTC Alli, this weight loss drug has milder side effects than Xenical.Xenical has the advantage of having been shown in clinical trials to reduce the onset of diabetes in obese patients.The Problem Patients Face When Taking Orlistat, Obesity Treatment and Weight Loss Drug
What are the Main Differences Between Xenical and OTC diet pill Alli?
Orlistat diet pill is available in prescription form as Xenical, and over-the-counter (OTC) as Alli. The purpose of this article is to inform patients of this alternative weight loss drug option.
Following the recent withdrawal of sibutramine (Reductil) in Europe, orlistat is the only approved diet pill for obesity treatment available. In addition, many patients in the USA may not be suitable for using Meridia following recent FDA resctrictions imposed on the weight loss drug.
For weight loss to occur with either weight loss drug, patients much take either Xenical o
Both weight loss drug options are approved as obesity treatments in patients with a body mass index (BMI) greater or equal to 30kg/m² [link widoczny dla zalogowanych], or for weight loss in overweight patients (BMI > 28kg/m² in Europe or BMI > 27kg/m² in USA) with associated risk factors, such as type 2 diabetes or dyslipidaemia, when used in conjunction with a reduced-calorie diet.
Orlistat is a lipase inhibitor, which means it acts to block the enzymes that break down fat in the gastrointestinal tract. As such, the diet pill induces weight loss by blocking fat absorption by the body. However, orlistat does not block all fat in the diet from being absorbed, and about 75% of the fat taken in still gets digested by the body.
Clinical studies have shown greater than 100% more weight loss when patients are treated with Xenical in combination with diet, compared to just diet alone. The efficacy of Alli for inducing weight loss, however, is around half of that seen for Xenical plus diet.
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